Investigating causal associations among gut microbiota, metabolites, and liver diseases: a Mendelian randomization study
نویسندگان
چکیده
Objective There is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic (ALD), viral hepatitis, but no studies have explored their causal relationship. Methods Instrumental variables of the (N = 13266) microbiota-derived metabolites 7824) were acquired, a Mendelian randomization study was performed to explore influence on NAFLD (1483 European cases 17,781 controls), ALD (2513 332,951 hepatitis risk (1971 340,528 controls). The main method examining causality inverse variance weighting (IVW). Results IVW results confirmed that Anaerotruncus ( p 0.0249), Intestinimonas 0.0237), Lachnoclostridium 0.0245), Lachnospiraceae NC2004 group 0.0083), Olsenella 0.0163), Peptococcus 0.0472) protective factors NAFLD, Ruminococcus 1 0.0120) detrimental NAFLD. higher abundance three genera, Lachnospira 0.0388), Desulfovibrio 0.0252), torques 0.0364), correlated with lower ALD, while Ruminococcaceae UCG 002 level associated 0.0371). Alistipes 0.0069) NK4A214 0.0195) related hepatitis. Besides, alanine 0.0076) phenyllactate 0.0100) found be negatively stachydrine (O 0.0244) positively phenylacetate 0.0353) ursodeoxycholate 0.0144) had effect threonate 0.0370) exerted ALD. estimates 0.0408) cholate 0.0293) showed suggestive harmful effects against 0.0401) displayed its Conclusion In conclusion, our research supported links microbiome
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2023
ISSN: ['1664-2392']
DOI: https://doi.org/10.3389/fendo.2023.1159148